Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain.

ABSTRACT: Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly understood. This study aimed to develop diamorphine population pharmacokinetics (pop-PK) models and simulate the IND dosing in virtual pediatric subjects. An integrated four-compartment pop-PK model with first-order absorption and elimination provided an appropriate fit and characterized publicly available 385 concentration measurements of diamorphine, 6-monoacetylmorphine, and morphine collected from adults. Body weight allometry and renal function matur

SUBMITTER: Cai L 

PROVIDER: S-EPMC11919270 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature