Multienzyme active melanin nanodots for antioxidant-immunomodulatory therapy of hyperoxia lung injury.

ABSTRACT: Supraphysiological oxygen is the most conventional method of treating patients with acute respiratory failure, but prolonged exposure to hyperoxia generates large amounts of reactive oxygen species (ROS) in the lungs, leading to hyperoxia lung injury (HLI). Nevertheless, there is no safe and effective prevention strategy. Herein, multienzyme active melanin nanodots were developed as an antioxidant-immunomodulatory defense nanoplatform for the treatment of HLI. The prepared nanodots are about 4 nm in size and are mainly composed of carbon, nitrogen and oxygen elements with high stability and multi-enzymatic activity for scavenging various reactive oxygen and reactive nitrogen radicals. Cellular experiments showed that melanin nanodots increased cell viability and ameliorated hyperoxia-induc

SUBMITTER: Sun J 

PROVIDER: S-EPMC11919337 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature