Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task.

ABSTRACT: Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease stages lack well-defined electrophysiological correlates, creating a critical gap in the identification of robust biomarkers for early diagnosis and intervention. In this study, we analysed event-related potentials (ERPs) recorded during a sustained visual attention task in a cohort of 178 individuals (119 SCD, 40 MCI, and 19 healthy subjects, HS) to investigate sensory and cognitive processing alterations associated with these conditions. SCD patients exhibited significant attenuation in both sensory (P1, N1, P2) and cognitive (P300, P600, P900) components compared to HS, with cognitive components showing performance-related gains. In contrast, MCI patients did not show a further decrease in any E

SUBMITTER: Vergani AA 

PROVIDER: S-EPMC11919406 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature