Lactiplantibacillus plantarum JM113 alleviates mitochondrial dysfunction induced by deoxynivalenol in the jejunum of broiler chickens.

ABSTRACT: Mitochondria are primary targets of deoxynivalenol (DON), which play a pivotal role in maintaining intestinal health. It has been suggested that Lactiplantibacillus plantarum JM113 (L. plantarum JM113) exhibits protective effects against the enterotoxicity of DON in broilers. However, the changes in mitochondrial homeostasis during this process remain unclear. A total of 144 one-day-old Arbor Acres broilers were randomly assigned to 3 groups, including the CON group (fed a basal diet and gavaged with 0.5 mL PBS), the DON group (supplemented with 5 mg/kg DON based on the CON group) and the DJ group (fed a basal diet challenged with 5 mg/kg DON and gavaged with 1 × 10⁹ CFU L. plantarum JM113). The results showed that deoxynivalenol damaged mitochondrial morphology in the jejunum,

SUBMITTER: Tong H 

PROVIDER: S-EPMC11919433 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature