Brief hypothermic oxygenated perfusion provides cardioprotection in a pig model of donation after circulatory death.

ABSTRACT:

Objectives

Donation after circulatory death provides excellent patient outcomes in heart transplantation; however, warm ischaemic graft damage remains a concern. We have reported that a brief period of hypothermic oxygenated perfusion prior to normothermic reperfusion improves graft recovery in a rat model. Here, we investigated the cardioprotective benefits and mechanisms of this approach compared to the current clinical standard in a large animal model.

Methods

Circulatory death was induced in anaesthetized male Schweizer Edelschwein pigs (55 kg). Hearts underwent 20 min of warm, in-situ ischaemia, followed by a cold coronary flush and explantation. After 15 min backtable preparation, hearts underwent either 15 min cold static storage (control) or 30 min hypothermic oxygen

SUBMITTER: Egle M 

PROVIDER: S-EPMC11919451 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature