Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions.

ABSTRACT:

Purpose

To show that intrinsic radiosensitivity varies greatly for protons and carbon (C) ions in addition to photons, and that DNA repair capacity remains important in governing this variability.

Methods

We measured or obtained from the literature clonogenic survival data for a number of human cancer cell lines exposed to photons, protons (9.9 keV/μm), and C-ions (13.3-77.1 keV/μm). We characterized their intrinsic radiosensitivity by the dose for 10% or 50% survival (D_10% or D_50% ), and quantified the variability at each radiation quality by the coefficient of variation (COV) in D_10% and D_50% . We also treated cells with DNA repair inhibitors prior to irradiation to assess how DNA repair capacity affects their variability.

Res

SUBMITTER: Flint DB 

PROVIDER: S-EPMC11919485 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature