Paramagnetic rim lesion formation is predicted by the initial gadolinium-enhancing lesion diameter.

ABSTRACT:

Background

Paramagnetic rim lesions (PRLs) are a magnetic resonance imaging (MRI) marker of compartmentalized intraparenchymal inflammation.

Objectives

The primary objective was to investigate clinical, demographic, and MRI factors that may be predictive of the future formation of PRL.

Methods

This is a retrospective analysis of longitudinal data. Patients were included if they had ⩾1 gadolinium-enhancing lesion on any historical MRI and follow-up scan(s) ⩾6 months afterward on a standardized 3T MRI using the filtered phase component of a susceptibility-sensitive sequence ("SWAN"). Regression and machine-learning models were used to identify the predictive ability of demographic, clinical, immunological, treatment-related, and MRI predictors of PRL formation.

Resul

SUBMITTER: Al Gburi M 

PROVIDER: S-EPMC11919566 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature