Clinical outcomes and risk factors for local failure and visual impairment in patients treated with Ru-106 brachytherapy for uveal melanoma.

ABSTRACT:

Background and purpose

Small uveal melanomas are preferably treated with eye-sparing therapies such as brachytherapy or proton beam therapy. Knowledge of clinical outcomes and risk factors is important for personalized patient counselling.

Materials and methods

Data of all choroidal melanoma patients treated at the Leiden University Medical Center between 2012-2019 with Ruthenium-106 brachytherapy were collected. Time-to-event analyses were performed with the Kaplan-Meier method, risk factors for local failure and visual acuity (VA) decline were identified using Cox proportional hazards models with predefined covariates.

Results

719 patients were included. Median tumour prominence and diameter were 3.8 mm and 11.6 mm, respectively. 52 % of tumours were centrally locat

SUBMITTER: Pors LJ 

PROVIDER: S-EPMC11919603 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature