Transcriptomic Alteration in the Brain and Gut of Offspring Following Prenatal Exposure to Corticosterone.

ABSTRACT: Maternal stress during pregnancy can profoundly affect offspring health, increasing the risk of psychiatric disorders, metabolic diseases, and gastrointestinal problems. In this study, the effects of high prenatal corticosterone exposure on gene expression in the brain and small intestine of rat offspring were investigated via RNA-sequencing analysis. Pregnant rats were divided into two groups: Corti.Moms were injected with corticosterone daily, while Nor.Moms were given saline injections. Their offspring were labeled as Corti.Pups and Nor.Pups, respectively. The brain tissue analysis of Corti.Pups showed that the expression levels of the genes linked to neurodegenerative conditions increased and enhanced mitochondrial biogenesis, possibly due to higher ATP demands. The genes associated wi

SUBMITTER: Ko EA 

PROVIDER: S-EPMC11919639 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature