Transcriptional and microbial profile of gastric cancer patients infected with Epstein-Barr virus.

ABSTRACT:

Introduction

Gastric cancer (GC), which has low survival rates and high mortality, is a major concern, particularly in Asia and South America, with over one million annual cases. Epstein-Barr virus (EBV) is recognized as a carcinogen that may trigger gastric carcinogenesis by infecting the stomach epithelium via reactivated B cells, with growing evidence linking it to GC. This study investigates the transcriptional and microbial profiles of EBV-infected versus EBV-non-infected GC patients.

Methods

Using Illumina NextSeq, cDNA libraries were sequenced, and reads were aligned to the human genome and analyzed with DESeq2. Kegg and differential analyses revealed key genes and pathways. Gene sensitivity and specificity were assessed using ROC curves (p < 0.05, AUC > 0.8). Non-ali

SUBMITTER: Carneiro KO 

PROVIDER: S-EPMC11919665 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature