The Evaluation of Patient-Controlled Analgesia Compared to Standard Opioid Analgesic Therapy in Pain Management Among Patients With Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol.

ABSTRACT:

Background and aims

Sickle cell disease (SCD) is an inherited blood disorder characterized by the production of abnormal hemoglobin S (HbS), leading to the deformation of red blood cells into a sickle shape under low oxygen conditions. These deformed cells impede blood flow, causing vaso-occlusive crises (VOCs), which result in severe pain, multiorgan damage, and increased mortality. Despite advancements in understanding the pathophysiology and management of VOCs, optimal pain management remains a significant challenge. This review aims to evaluate patient-controlled analgesia compared to standard opioid analgesic therapy in pain management among patients with SCD.

Methods

The relevant studies will be searched using a well-formulated search strategy using databases such as P

SUBMITTER: D'Costa MP 

PROVIDER: S-EPMC11919697 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature