Gene expression differences associated with alcohol use disorder in human brain.

ABSTRACT: Excessive alcohol consumption is a leading cause of preventable death worldwide. To improve understanding of neurobiological mechanisms associated with alcohol use disorder (AUD) in humans, we compared gene expression data from deceased individuals with and without AUD across two addiction-relevant brain regions: the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC). Bulk RNA-seq data from NAc and DLPFC (N ≥50 with AUD, ≥46 non-AUD) were analyzed for differential gene expression using modified negative binomial regression adjusting for technical and biological covariates. The region-level results were meta-analyzed with those from an independent dataset (N_NAc = 28 AUD, 29 non-AUD; N_PFC = 66 AUD, 77 non-AUD). We further tested for heritability enrichme

SUBMITTER: Willis C 

PROVIDER: S-EPMC11919698 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature