Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues.

ABSTRACT: While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on the basis of chromatin accessibility and histone modification patterns, delineating their role in developmentally regulated gene expression continues to be challenging. To fill this gap, here we mapped chromatin contacts between gene promoters and distal sequences across the genome in seven mouse fetal tissues and across six developmental stages of the forebrain. We identified 248,620 long-range chromatin interactions centered at 14,138 protein-coding genes and characterized their tissue-to-tissue variations and developmental dynamics. Integrative analysis of the interactome with previous epigenome and transcriptome datasets from the same tissues revealed a strong corre

SUBMITTER: Yu M 

PROVIDER: S-EPMC11919700 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature