Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology.

ABSTRACT: Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by sex/gender among cognitively unimpaired older adults at increased risk of developing AD. We included 397 participants from the ALFA+ cohort with CSF Aβ_42/40, p-tau₁₈₁, sTREM2, YKL40, and GFAP, magnetic resonance imaging-based hippocampal volume (n = 299), and amyloid burden (centiloids) measured with [¹⁸F] flutemetamol positron emission tomography (n = 341). We ran multiple linear regression models to assess the association between glial markers, AD pathology and hippocampal volumes and their interaction with sex/gender, using F

SUBMITTER: Vila-Castelar C 

PROVIDER: S-EPMC11919761 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature