Role of right dorsolateral prefrontal cortex-left primary motor cortex interaction in motor inhibition in Parkinson's disease.

ABSTRACT:

Background

Impaired motor inhibition in Parkinson's disease (PD) is associated with functional alterations in the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary motor area (pre-SMA), and primary motor cortex (M1) play key roles in regulating this inhibition. However, the changes in interhemispheric interactions during motor inhibition in PD have not been clearly defined.

Methods

We used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to examine the interactions between the right DLPFC and pre-SMA and the left M1 in 30 patients with early-stage PD and 30 age-matched healthy controls (HC) during both resting and active conditions, specifically while performing a stop-signal task (SST).

Results

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11919838 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature