Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis.

ABSTRACT:

Introduction

Cluster of differentiation 36 (CD36) is highly expressed in the liver of patients with metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatohepatitis (MASH). However, the precise role of CD36 in MAFLD/MASH is controversial. In the current study, we aimed to uncover the role of CD36 in the early stage of MAFLD/MASH induced by high-fat diet (HFD) and methionine/choline-deficient (MCD) diet.

Methods

CD36^-/- mice and littermate control mice were fed a normal food diet (NCD); HFD or MCD diet for 6 weeks.

Results

We determined that CD36 deficiency attenuated HFD-induced hepatic steatosis while exacerbating MCD diet-induced steatohepatitis. Mechanistically, CD36 deficiency reduced HFD-induced expressio

SUBMITTER: Zhu W 

PROVIDER: S-EPMC11919839 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature