Genetic discrimination in insurance and employment based on personalized risk stratification for breast cancer screening.

ABSTRACT:

Background

The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) incorporates the effects of common genetic variants, from polygenic risk scores, pathogenic variants in major breast cancer (BC) susceptibility genes, lifestyle/hormonal risk factors, mammographic density, and cancer family history to predict risk levels of developing breast and ovarian cancer. While offering multifactorial risk assessment to the population could be a promising avenue for early detection of BC, obstacles to its implementation including fear of genetic discrimination (GD), could prevent individuals from undergoing screening.

Methods

The aim of our study was two-fold: determine the extent of legal protection in Canada available to protect information gen

SUBMITTER: Reveiz M 

PROVIDER: S-EPMC11919849 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature