The systemic inflammation markers as potential predictors of disease progression and survival time in amyotrophic lateral sclerosis.

ABSTRACT:

Introduction

Amyotrophic lateral sclerosis (ALS) is a fatal and untreatable neurodegenerative disease with only 3-5 years' survival time after diagnosis. Inflammation has been proven to play important roles in ALS progression. However, the relationship between systemic inflammation markers and ALS has not been well established, especially in Chinese ALS patients. The present study aimed to assess the predictive value of systemic inflammation markers including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic immune-inflammation index (SII) for Chinese amyotrophic lateral sclerosis (ALS).

Methods

Seventy-two Chinese ALS patients and 73 controls were included in this study. The rate of disease progression

SUBMITTER: Hong Y 

PROVIDER: S-EPMC11919871 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature