Jidangga-7 ameliorates non-small cell lung cancer by regulating gut microbiota function.

ABSTRACT:

Objective

This study aims to assess the effects of Jidangga-7 on enhancing gut microbiota function in non-small cell lung cancer.

Materials and methods

Eighteen mice were screened and randomly divided into three groups: a control group, a model group with induced non-small cell lung cancer, and a treatment group receiving Jidangga-7. A549 tumor cells were implanted in the mice, and tumor formation was monitored. Upon successful tumor induction, the treatment group received Jidangga-7 via oral gavage, while the other groups received an equivalent volume of saline. After the final dose, intestinal tissues were collected from each group, and microbial amplicon 16S analysis and non-extensive targeted metabolomics were employed to characterize intestinal fiber and associated meta

SUBMITTER: Yue C 

PROVIDER: S-EPMC11919877 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature