Enterobactin and salmochelin S4 inhibit the growth of <i>Staphylococcus aureus</i>.

ABSTRACT: There is increasing demand for novel antimicrobial agents to tackle the antimicrobial resistance crisis. Here we report that two Enterobacteriaceae-produced siderophores, enterobactin and salmochelin S4, inhibit the growth of Staphylococcus aureus isolates, including methicillin-resistance S. aureus (MRSA) clinical isolates. The IC₅₀ for different S. aureus isolates were 2-5 µM for salmochelin S4 and 5-10 µM for enterobactin. This inhibitory activity was partially repressed by adding Fe⁺³. These siderophores also inhibited the growth of Enterococcus strains, including vancomycin-resistant enterococci (VRE) clinical isolates, though less effectively than for S. aureus. The growth of various Gram-negative bacteria was barely aff

SUBMITTER: Davidov Y 

PROVIDER: S-EPMC11919883 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature