Identifying pathological myopia associated genes with GenePlexus in protein-protein interaction network.

ABSTRACT:

Introduction

Pathological myopia, a severe form of myopia, is characterized by an extreme elongation of the eyeball, leading to various vision-threatening complications. It is broadly classified into two primary types: high myopia, which primarily involves an excessive axial length of the eye with potential for reversible vision loss, and degenerative myopia, associated with progressive and irreversible retinal damage.

Methods

Leveraging data from DisGeNET, reporting 184 genes linked to high myopia and 39 genes associated with degenerative myopia, we employed the GenePlexus methodology in conjunction with screening tests to further explore the genetic landscape of pathological myopia.

Results and discussion

Our comprehensive analysis resulted in the discovery of 21 ne

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11919901 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature