Maximizing the accuracy of genetic variance estimation and using a novel generalized effective sample size to improve simulations.

ABSTRACT:

Key message

We developed an improved variance estimation that incorporates prediction error variance as a correction factor, alongside a novel generalized effective sample size to enhance simulations. This approach enables precise control of variance components, accommodating for more flexible and accurate simulations. Phenotypic variation in field trials results from genetic and environmental factors, and understanding this variation is critical for breeding program simulations. Additive genetic variance, a key component, is often estimated using linear mixed models (LMM), but can be biased due to improper scaling of the genomic relationship matrix. Here, we show that this bias can be minimized by incorporating prediction error variance (PEV) as a correction factor. Our results de

SUBMITTER: Fernandez-Gonzalez J 

PROVIDER: S-EPMC11919955 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature