Inactivation of multidrug-resistant bacteria using cold atmospheric-pressure plasma technology.

ABSTRACT:

Objective

This study aimed to investigate the impact of cold atmospheric-pressure plasma (CAP) on multidrug-resistant (MDR) bacteria on various surfaces under nosocomial circumstances and the underlying mechanism.

Method

Four common MDR bacteria (carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and carbapenem-resistant Klebsiella pneumoniae) were inoculated on nosocomial surfaces, which were subsequently exposed to CAP. Then the bacteria from surfaces were recovered and diluted. The killing curve was analyzed to evaluate the sterilization effects of CAP. Electron microscopy was used to evaluate the changes in cell morphology.

Result

In the CAP-producing d

SUBMITTER: Wang X 

PROVIDER: S-EPMC11920159 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature