Non-chemotherapy drugs inducing agranulocytosis: a disproportionality analysis based on the FAERS database.

ABSTRACT:

Introduction

Non-chemotherapy drug-induced agranulocytosis (NCDIA) is a serious adverse reaction that significantly increases the risk of life-threatening infections. Although the association between certain non-chemotherapy drugs and agranulocytosis has been documented, a comprehensive analysis using a large-scale pharmacovigilance database is lacking. This study aimed to systematically identify and characterize NCDIA by analyzing adverse event reports from the FAERS database.

Methods

We conducted a retrospective analysis of NCDIA reports from the FAERS database spanning from 2004 to 2024 Q1. Drugs were classified using the Anatomical Therapeutic Chemical (ATC) classification system, with chemotherapy agents (ATC code L01) excluded. The Reporting Odds Ratio (ROR) method was

SUBMITTER: Wu S 

PROVIDER: S-EPMC11920160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature