Population genomic analysis identifies the complex structural variation at the fibromelanosis (FM) locus in chicken.

ABSTRACT: Phenotypic diversity and its genetic basis are central questions in biology, with domesticated animals offering valuable insights due to their rapid evolution the last 10,000 years. In chickens, fibromelanosis (FM) is a striking pigmentation phenotype characterized by hyperpigmentation. A previous study identified a complex structural variant involving both two large duplications (127.4 and 170.5 kb in size) and inversions associated with upregulated expression of the Endothelin 3 (EDN3) gene. However, the detailed organization of the structural arrangements have remained unclear. In this study, we conducted a comprehensive genomic survey of 517 FM chickens representing 44 different populations. Our results elucidate the complex arrangement of the duplications and inversions at the FM locu

SUBMITTER: Ma C 

PROVIDER: S-EPMC11920206 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature