Identification of hub genes between moderate to severe asthma and early lung adenocarcinoma through bioinformatics analysis.

ABSTRACT: The objective of this study was to explore the genetic link between moderate to severe asthma and early-stage lung adenocarcinoma (LUAD) using bioinformatic methods. The Cancer Genome Atlas gene-expression profiles for early-stage LUAD and GSE76225 data set for moderate to severe asthma were selected for weighted gene co-expression network analysis, and intersected with the relevant module genes and selected hub genes; the relevant network of hub genes was then determined through a protein-protein interaction network. In addition, gene-set enrichment analysis and gene-set variation analysis (GSVA) were conducted on differentially expressed genes between normal and tumor groups. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway-enrichment analyses were applied to detect hub

SUBMITTER: Xue J 

PROVIDER: S-EPMC11920247 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature