Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice.

ABSTRACT: Bone resorption by osteoclasts is a critical step in bone remodeling, a process important for maintaining bone homeostasis and repairing injured bone. We previously identified a bone marrow mesenchymal subpopulation, marrow adipogenic lineage precursors (MALPs), and showed that its production of RANKL stimulates bone resorption in young mice using Adipoq-Cre. To exclude developmental defects and to investigate the role of MALPs-derived RANKL in adult bone, we generated inducible reporter mice (Adipoq-CreER Tomato) and RANKL deficient mice (Adipoq-CreER RANKLflox/flox, iCKO). Single cell-RNA sequencing data analysis and lineage tracing revealed that Adipoq⁺ cells contain not only MALPs but also some mesenchymal progenitors capable of osteogenic differentiation. In situ hybridizat

SUBMITTER: Lu J 

PROVIDER: S-EPMC11920254 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature