Characterizing the effect of impeller design in plant cell fermentations using CFD modeling.

ABSTRACT: Cultivation of plant cell cultures in conventional bioreactors designed for microbial cells often results in decrease of biomass productivity as compared to that in shake flasks, presumably due to the imbalance between the mass transfer requirements and compromise with cell viability. Hit and trial methods for bioreactor design are generally performed to achieve high biomass productivity in the bioreactor. In this study, a rational approach has been adopted to choose a suitable impeller for Viola odorata cell suspension culture using computational fluid dynamics (CFD). A two-phase CFD model was employed to characterize the non-Newtonian fluid dynamics of the plant cell suspension in a stirred tank reactor using different impeller designs, a setric, Rushton and marine impeller. The simulati

SUBMITTER: Manickavasagam VM 

PROVIDER: S-EPMC11920266 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature