Imputation of missing clock times - application to procalcitonin concentration time course after birth.

ABSTRACT: The time course of biomarkers (e.g., acute phase proteins) are typically described using days relative to events of interest, such as surgery or birth, without specifying the sample time. This limits their use as they may change rapidly during a single day. We investigated strategies to impute missing clock times, using procalcitonin for population modelling as the motivating example. 1275 procalcitonin concentrations from 282 neonates were available with dates but not sample times (Scenario 0). Missing clock times were imputed using a random uniform distribution under three scenarios: (1) minimum sampling intervals (8-12 h); (2) procalcitonin concentrations increase for postnatal days 0-1 then decrease; (3) standard sampling practice at the study hospital. Unique datasets (n = 100) were c

SUBMITTER: Bokor AJ 

PROVIDER: S-EPMC11920349 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature