Development and validation of cancer-specific survival prediction nomogram for patients with T4 stage colon cancer after surgical resection: a population-based study.

ABSTRACT:

Purpose

The increasing incidence of colorectal cancer has coincided with a rise in T4 stage colon cancer (CC), yet research on its prognosis remains limited. This study aimed to identify risk factors and develop a nomogram to predict cancer-specific survival (CSS), optimizing treatment strategies for different subgroups.

Methods

Using data from the from the Surveillance, Epidemiology, and End Results (SEER) database, we identified risk factors in T4 stage CC patients and created a nomogram to predict CSS. Patients were divided into low- and high-risk groups, and the nomogram was validated. Propensity score matching was used to evaluate the benefits of various therapies across subgroups.

Results

Independent risk factors, including T stage, N stage, tumor grade, age, an

SUBMITTER: Xing Y 

PROVIDER: S-EPMC11920356 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature