Aggressive ablation vs. regular ablation for persistent atrial fibrillation: a multicentre real-world cohort study.

ABSTRACT:

Aims

Current guidelines for the optimal ablation strategy for persistent atrial fibrillation (PerAF) remain unclear. While our previous RCT confirmed the favourable prognosis of aggressive ablation, real-world evidence is still lacking.

Methods and results

Among 4833 PerAF patients undergoing catheter ablation at 10 centres, two groups were defined: regular ablation (PVI-only or PVI plus anatomical ablation) and aggressive ablation (anatomical plus electrogram-guided ablation), with 1560 patients each after propensity score (PS) matching. The primary endpoint was 12-month AF/atrial tachycardia (AT) recurrence-free survival off anti-arrhythmic drugs after a single procedure. Additional PS matching was performed within the regular group between PVI-only and anatomical ablation

SUBMITTER: Li K 

PROVIDER: S-EPMC11920505 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature