Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study.

ABSTRACT:

Background

Reliable dosimetry based on SPECT/CT imaging is essential to achieve personalized ¹⁶⁶Ho-radioembolization treatment planning and evaluation. This study quantitatively evaluates multiple acquisition and reconstruction protocols for ¹⁶⁶Ho-SPECT imaging based on data from five Dutch hospitals. We aim to recommend an imaging protocol which harmonizes ¹⁶⁶Ho-SPECT images for reproducible and accurate dosimetry in a multi-scanner and multi-center setting.

Methods

Cylindrical and NEMA IEC phantoms, filled with ¹⁶⁶Ho-chloride, were imaged using seven SPECT/CT scanners from two vendors (GE HealthCare and Siemens Healthineers). Data were acquired with a photopeak window centered at 81 keV. Two adjacent scatter windows, and one uppe

SUBMITTER: Westlund Gotby LEL 

PROVIDER: S-EPMC11920561 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature