Predictive factors for outcome in HER2-low breast cancer patients after neoadjuvant chemotherapy.

ABSTRACT:

Objective

The present study aimed to evaluate the predictive factors that predict outcomes of HER2-low breast cancer patients who did not achieve pathological complete response(pCR) after neoadjuvant chemotherapy (NAC).

Methods

This study included patients with HER2-low breast cancer who received NAC from January 2017 to December 2020. Analysis of the clinicopathological features, NAC response and outcome of the patients were retrospectively analyzed. Univariate and multivariable Cox analysis were used to determine factors that predict outcomes of HER2-low breast cancer patients who did not exhibit pCR.

Results

293 Asian patients were included. The proportion of patients with hormone receptor (HR) positive and triple negative breast cancer (TNBC) among HER2-low patien

SUBMITTER: Shao Y 

PROVIDER: S-EPMC11920645 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature