Evaluating oxidative stress targeting treatments in <i>in vitro</i> models of placental stress relevant to preeclampsia.

ABSTRACT:

Background

Preeclampsia is a complex pregnancy disorder characterized by the new onset of hypertension and organ dysfunction, often leading to significant maternal and fetal morbidity and mortality. Placental dysfunction is a hallmark feature of preeclampsia, which is often caused by inappropriate trophoblast cell function in association with oxidative stress, inflammation and/or pathological hypoxia. This study explores the role of oxidative stress in trophoblast cell-based models mimicking the preeclamptic placenta and evaluates potential therapeutic strategies targeting these mechanisms.

Methods

Uric acid (UA) and malondialdehyde (MDA) concentrations were measured in human plasma from women with preeclampsia (n = 24) or normotensive controls (n = 14) using colorimetric as

SUBMITTER: Afrose D 

PROVIDER: S-EPMC11920713 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature