Ethnoracial disparities in gray matter atrophy are mediated by structural disconnectivity in multiple sclerosis.

ABSTRACT:

Objective

To investigate ethnoracial disparities in gray matter (GM) atrophy, the contribution of white matter lesions and consequent structural disconnectivity among patients with multiple sclerosis (MS).

Methods

This retrospective study included 297 patients with MS (pwMS), 98 Hispanic/Latinx (H-MS), 82 non-Hispanic Black (B-MS), and 117 non-Hispanic White (W-MS). GM atrophy was assessed using univariate, voxel-based morphometry, and multivariate techniques, source-based morphometry. Structural disconnectivity secondary to white matter lesions was evaluated using the network modification tool. Mediation analyses explored relationships between ethnoracial groups, white matter lesions, structural disconnectivity, and gray matter atrophy.

Results

B-MS and H-MS generall

SUBMITTER: Bayoumi A 

PROVIDER: S-EPMC11920733 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature