Coexistence of acute myeloid leukemia with a complex chromosomal translocation and monoclonal gammopathy of undetermined significance: A case report and literature review.

ABSTRACT: Acute myeloid leukemia (AML) with chromosomal translocation t(8;21)(q22;q22.1) is a rare subtype, accounting for 4-8% of all cases of AML. Despite its rarity, it has a favorable outcome. The translocation event culminates in the formation of the Runt-related transcription factor 1 (RUNX1)::RUNX1 partner transcriptional co-repressor 1 (RUNX1T1) fusion protein, which is implicated in hematopoietic differentiation and maturation. Furthermore, monoclonal gammopathy of undetermined significance (MGUS) is characterized by the presence of monoclonal immunoglobulins in the blood or urine, serum M protein level of <3 g/dl and <10% clonal plasma cells in the bone marrow, with no accompanying end-organ damage associated with myeloma. The simultaneous occurrence of AML and MGUS is exceedingly rare. Th

SUBMITTER: Qiao X 

PROVIDER: S-EPMC11920776 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature