Changes in Adrenal Function and Insufficiency Symptoms After Cessation of Prednisolone.

ABSTRACT:

Importance

The widespread use of glucocorticoid (GC) therapy may result in GC-induced adrenal insufficiency (GIAI), but the prevalence and clinical implications remain uncertain.

Objective

To ascertain the prevalence and symptoms of GIAI.

Design, setting, and participants

Cross-sectional multicenter study at 3 Danish hospitals. Baseline data were collected March 2021 to March 2024 from an ongoing randomized clinical trial. Participants were patients with polymyalgia rheumatica and/or giant cell arteritis who were investigated a median (IQR) of 39 (25-62) days after planned cessation of prednisolone treatment.

Exposure

Prednisolone treatment a median (IQR) of 13 (10-20) months in duration.

Main outcomes and measures

Primary outcome GIAI was defined as a s

SUBMITTER: Hansen SB 

PROVIDER: S-EPMC11920843 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature