Clinical and Genomic Characterization of Secondary Rectal Cancer After Radiotherapy for Prostate Cancer.

ABSTRACT:

Importance

Patients treated with radiotherapy (RT) for prostate cancer (PC) have increased risk of secondary rectal cancer (SRC) and more limited treatment options.

Objective

To assess the tumor molecular profile, clinical characteristics, and oncologic outcomes of SRC after PC and compare them with those of primary rectal cancer (PRC).

Design, setting, and participants

This case-control study included patients with SRC diagnosed 5 or more years after RT for PC and patients with PRC who were treated at Memorial Sloan Kettering Cancer Center in New York between February 1, 1994, and September 31, 2022.

Main outcomes and measures

Clinical information and DNA sequencing data were analyzed. Oncologic outcomes were compared between patients with SRC and clinically m

SUBMITTER: Omer DM 

PROVIDER: S-EPMC11920846 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature