Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.

ABSTRACT:

Background

Asthma is a heterogeneous disease characterized by overlapping clinical and inflammatory features.

Objective

This study aimed to provide insight into the systemic inflammatory profile in asthma, greater understanding of asthma endotypes and the contribution of genetic risk factors to both.

Methods

4205 patients with asthma aged 16-60 were recruited from UK centers; serum cytokines were quantified from 708, including cytokines associated with Type 1, 2 and 17 inflammation. 3037 patients were genotyped for 25 single nucleotide polymorphisms associated with moderate-severe asthma.

Results

Serum cytokines associated with Th2 inflammation showed high coordinated expression for example, IL-4/IL-5 (R² = 0.513). The upper quartile of the serum cyt

SUBMITTER: Bingham K 

PROVIDER: S-EPMC11920881 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature