Comparative effectiveness of metronidazole and vancomycin for treatment of <i>Clostridioides difficile</i> infection in hospitalized children.

ABSTRACT:

Objective

To compare rates of clinical response in children with Clostridioides difficile infection (CDI) treated with metronidazole vs vancomycin.

Design

Retrospective cohort study was performed as a secondary analysis of a previously established prospective cohort of hospitalized children with CDI. For 187 participants 2-17 years of age who were treated with metronidazole and/or vancomycin, the primary outcome of clinical response (defined as resolution of diarrhea within 5 days of treatment initiation) was identified retrospectively. Baseline variables associated with the primary outcome were included in a logistic regression propensity score model estimating the likelihood of receiving metronidazole vs vancomycin. Logistic regression using inverse probability of t

SUBMITTER: Sandora TJ 

PROVIDER: S-EPMC11920915 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature