Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach.

ABSTRACT: Antimicrobial resistance is one of the biggest global healthcare challenges. Therefore, there is an urgent need to develop new molecules that display distinct antibacterial properties to overcome resistance. With this aim, we have developed a combinatorial and semiautomated platform to synthesize and screen a library of 78 compounds against Gram-positive and Gram-negative bacteria. This library is based on octahedral iridium(III) complexes with general formula [Ir(CN)₂(NN)]Cl (where CN are cyclometallating polyaromatic ligands and NN are phenanthroline-imidazole or dipyridophenazine derivatives) which are known to generate reactive oxygen species (ROS) upon light irradiation. From the initial screen of the entire library (in the dark and under light i

SUBMITTER: Kench T 

PROVIDER: S-EPMC11920948 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature