Global, Regional, and National Burden of Early-Onset Alzheimer's Disease and Other Dementias in Young Adults Aged 40-64 Years, 1990-2021: A Population-Based Study.

ABSTRACT:

Background and purpose

Early-onset Alzheimer's disease and other dementias (EOAD) impose significant burdens on affected individuals and their families. However, the global burden of EOAD has not been fully investigated. We aimed to assess the global, regional, and national burden of EOAD using data from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) study from 1990 to 2021.

Methods

Data for adults aged 40-64 were extracted within the GBD 2021 framework. Primary outcomes included age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) for EOAD, as well as average annual percentage change (AAPC) across 21 regions and 204 countries.

Results

In 2021, EOAD cases reached 7.75 million (95% uncertainty interval [UI] 5.82

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11921012 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature