Mucin Coatings Establish Multifunctional Properties on Commercial Sutures.

ABSTRACT: During the wound healing process, complications such as bacterial attachment or inflammation may occur, potentially leading to surgical site infections. To reduce this risk, many commercial sutures contain biocides such as triclosan; however, this chemical has been linked to toxicity and contributes to the occurrence of bacterial resistance. In response to the need for more biocompatible alternatives, we here present an approach inspired by the innate human defense system: utilizing mucin glycoproteins derived from porcine mucus to create more cytocompatible suture coatings with antibiofouling properties. By attaching manually purified mucin to commercially available sutures through a simple and rapid coating process, we obtain sutures with cell-repellent and antibacterial properties towar

SUBMITTER: Gurer U 

PROVIDER: S-EPMC11921033 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature