Identification of virulence-related amino acid mutations of avian encephalomyelitis virus associated with vaccination methods.

ABSTRACT: Avian encephalomyelitis virus (AEV), a picornavirus, primarily infects the central nervous system of 1 to 2-week-old young chickens but not pullets. When wild-type AEV undergoes serial passaging in chicken embryos, it becomes to be embryo-adapted and can cause avian encephalomyelitis in chickens of all ages following intracutaneous infection through parenteral routes. This study was conducted to explore whether an outbreak of AEV in 95-day-old chickens was linked to inadvertent embryo adaptation of the AEV vaccine and its association with vaccination method. In this study, an AEV strain AEV/JS202201 was isolated from the flocks of chickens that had been shortly after vaccinated with the AEV vaccine combined with the avian pox vaccine by the wing-web method. Whole-genome sequencing was perf

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11921046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature