Identification of diagnostic biomarkers of and immune cell infiltration analysis in bovine respiratory disease.

ABSTRACT:

Background

Bovine respiratory disease (BRD) is a prevalent and costly condition in the cattle industry, impacting long-term productivity, antibioticusage, and global food safety. Thus, identifying reliable biomarkers for BRD is crucial for early diagnosis, effective treatment, and monitoring therapeutic outcomes.

Methods

This study identified differentially expressed genes (DEGs) associated with BRD by analyzing a blood RNA-seq expression dataset associated with BRD, and conducted a Kyoto Encyclopedia of Genes and Genomes (KEGG) approach enrichment and Gene Ontology (GO) annotation analysis on these DEGs. Meanwhile, the key modules related to BRD were screened by weighted gene co-expression network analysis (WGCNA), and the genes in the module were intersected with DEGs. Sub

SUBMITTER: Sheng H 

PROVIDER: S-EPMC11921050 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature