Exploring NamiRNA networks and time-series gene expression in osteogenic differentiation of adipose-derived stem cells.

ABSTRACT:

Background

Adipose-derived stem cells (ADSCs) are a type of stem cell found in adipose tissue with the capacity to differentiate into multiple lineages, including osteoblasts. The differentiation of ADSCs into osteoblasts underlies osteogenic and pathological cellular basis in osteoporosis, bone damage and repair.

Methods

Focused on ADSCs osteogenic differentiation, we conducted mRNA, microRNA expression and bioinformatics analysis, including gene differential expression, time series-based trend analysis, functional enrichment, and generates potential nuclear activating miRNAs (NamiRNA) regulatory network. The screened mRNAs in NamiRNA regulatory network were validated with correlation analysis.

Results

The NamiRNA Regulatory Network reveals 4 mRNAs (C12orf61, MIR31HG

SUBMITTER: Jin X 

PROVIDER: S-EPMC11921168 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature