Correlation of renal function with intra-patient variability of tacrolimus concentration among recipients of renal transplants: a 10-year study.

ABSTRACT:

Background

Tacrolimus is one of the most commonly used basic immunosuppressants nowadays, but the high variability of tacrolimus blood concentration often leads to kidney transplant recipients frequently experiencing drug concentrations above or below the target concentration, resulting in renal toxicity or rejection of the transplanted kidney. The aim of this study is to explore the correlation of renal function with intra-patient variability (IPV) of tacrolimus blood concentration among recipients of renal transplants at 1-, 3-, 5-, and 10-year post-transplantation.

Methods

Recipients of renal transplants who were treated with tacrolimus for immunosuppression at the Shanghai General Hospital between January 2001 and December 2009, and followed up until 2019 were included i

SUBMITTER: Qin Y 

PROVIDER: S-EPMC11921183 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature