A transdiagnostic systematic review and meta-analysis of ketamine's anxiolytic effects.

ABSTRACT:

Background

Ketamine may be effective in treating symptoms of anxiety, but the time profile of ketamine's anxiolytic effect is ill-defined. This systematic review and meta-analysis investigated the anxiolytic effect of ketamine at different time points across a range of clinical settings.

Methods

Electronic databases were searched to capture randomised control trials measuring the anxiolytic effects of ketamine in contexts including mood disorders, anxiety disorders and chronic pain. Meta-analyses were conducted using a random-effects model. The correlations between (1) improvements in mean anxiety and depression scores, and (2) peak dissociation and improvements in mean anxiety scores were also assessed.

Results

In all, 14 studies met inclusion criteria. Risk of bias

SUBMITTER: Hartland H 

PROVIDER: S-EPMC11921208 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature