Liver microsomal protein content and activity in patients with hepatocellular carcinoma and cirrhosis: implications for the <i>in vivo</i> prediction of individual hepatic clearance.

ABSTRACT:

Background

The hepatic metabolism of patients with hepatocellular carcinoma and cirrhosis (HCCC) may differ from that of patients with hepatocellular carcinoma (HCC) without cirrhosis, limiting the clinical individualized dosing regimens for these patients. Microsomal protein per gram of liver (MPPGL) is an important scaling factor for physiologically based pharmacokinetic models, but data in patients with HCCC are limited. The study aims to determine the content of MPPGL in patients with HCCC and to guide individualized clinical dosing of patients with HCCC using in vitro drug metabolism data.

Methods

The microsomal protein content was determined in liver samples of patients with HCCC (n=48) and in normal liver samples (n=68). The activity of 10 cytochrome P450 (CYP)

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11921222 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature