Insights into the single-cell transcriptome characteristics of porcine endometrium with embryo loss.

ABSTRACT: Reproductive disorders are a concern in the pig industry. Successful gestation processes are closely related to a suitable endometrial microenvironment, and the physiological mechanisms leading to failed pregnancy during the peri-implantation period remain unclear. We constructed single-cell transcriptome profiles of peri-implantation embryo loss and successful gestation endometrial tissues and identified 22 cell subpopulations, with epithelial and stromal cells being the predominant endometrial cell types. The two tissues showed marked differences in cell type composition, especially among epithelial cell subpopulations. We also observed functional differences between epithelial and stromal cells in tissues from embryonic loss and successful gestation, as well as the expression levels and

SUBMITTER: Chu T 

PROVIDER: S-EPMC11921279 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature